Summary

This document shows the utility of DGH-GO in exploring or studying the shared etiology of complex diseases (Autism Spectrum Disorder (ASD), Schizophrenia and Biplolar disorder).

Input genes

## preparing gene to GO mapping data...
## preparing IC data...
## [1] 3185    2
##      genes         class
## 1    ABCB9 Schizophrenia
## 2      ACD Schizophrenia
## 3    ACTR5 Schizophrenia
## 4 ADAMTSL3 Schizophrenia
## 5     AKT3 Schizophrenia
## 6    ALDOA Schizophrenia
## [1] 2594
## 
##           ASD       Bipolar Schizophrenia 
##           942          1021          1222

Exploratory plots of input

Dimension Reduction

Pricipal Coordinate Analysis

## [1] 2245 2247

T-SNE

Clustering

Agglomerative hierarchical clustering

## Warning: `gather_()` was deprecated in tidyr 1.2.0.
## Please use `gather()` instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was generated.
##   cluster size ave.sil.width
## 1       1  968         -0.11
## 2       2  514         -0.24
## 3       3  763          0.49

## [1] 763   3
##    genes                     class cluster
## 5  ABCA7                       ASD       3
## 13   ACD             Schizophrenia       3
## 14   ACE Schizophrenia,Bipolar,ASD       3
## 23  ACTB                       ASD       3
## 25 ACTN4                       ASD       3
## 26 ACTR5             Schizophrenia       3
## 
##                       ASD                   Bipolar               Bipolar,ASD 
##                       251                       135                        31 
##             Schizophrenia         Schizophrenia,ASD     Schizophrenia,Bipolar 
##                       193                        39                        85 
## Schizophrenia,Bipolar,ASD 
##                        29

Functional enrichment analysis

Enriched Human Phenotype Ontology terms

Enriched GO terms

Enriched KEGG Pathways